Manage your weight and still enjoy your meals with Plenity. It’s the first and only FDA-cleared adult weight management tool made from naturally derived building blocks.

Supply will be limited. Sign up to be the first to know when it’s available.

For the time being, Plenity will not be available in Florida or Virginia.

Treatment benefits

Plenity responders lost 22 pounds, on average

Free follow-ups with a Ro network physician

Clinically tested and FDA-cleared

Stimulant free and non-habit forming

How it works

Plenity is a capsule taken with water before lunch and dinner. Plenity absorbs the water you drank and mixes with the food you eat. This makes you feel full and helps you eat less. With continued use, you’ll feel fuller throughout the day.

Take the capsules

Take three Plenity capsules before you eat lunch and dinner.

Drink water

Pair your Plenity capsules with a 16-ounce bottle of water or two 8-ounce glasses of water.

Feel fuller

Wait 20 minutes to eat after taking your Plenity capsules, and you’ll feel full after eating smaller portions.

You’ve got questions? We’ve got answers.

Plenity is an innovative weight management tool. And since Plenity is new, we encourage you to explore a few important questions and find out if Plenity is right for you.

How long can I take it?

Plenity is not a stimulant and there is no restriction on how long it can be used.

Is it natural?

Plenity is made from two naturally derived building blocks—cellulose and citric acid.

Are there any side effects?

There was no overall difference in side effects between placebo and Plenity. The most common side effects were fullness, bloating, flatulence, diarrhea, and/or abdominal pain.

Is it safe?

Plenity has been shown in a clinical study to have a proven safety profile and is as well-tolerated as placebo.

Your day-to-day life with Plenity

Watch this video to find out how Plenity would look in your daily routine.

Plenity’s clinical trial—
Gelesis Loss of Weight (GLOW) study

In a six-month clinical trial called GLOW (Gelesis Loss of Weight), 436 participants were randomly prescribed Plenity or placebo. All participants were also required to reduce their caloric intake and exercise. After 24 weeks, adults that used Plenity lost approximately 50% more weight than those who took the placebo.

The study was designed to measure: whether at least 35% of individuals receiving Plenity lost 5% of their body weight, whether individuals receiving Plenity lost 3% more of their body weight than individuals receiving placebo. Study results showed that nearly 60% of adults treated with Plenity lost at least 5% of their body weight. Individuals on Plenity lost on average 6% vs. individuals on placebo, who lost on average 4%. The overall incidence of adverse events was no different between placebo and Plenity.

Important Safety Information

Plenity is indicated to aid in weight management in overweight and obese adults with a Body Mass Index (BMI) of 25 – 40 kg/m^2, when used in conjunction with diet and exercise.

Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium oxide should not take Plenity.

To avoid impact on the absorption of medications:

  • For all medications that should be taken with food, take them after starting a meal.
  • For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician.

Contact a doctor right away if problems occur. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor.

Plenity is a prescription-only therapy. For the safe and proper use of Plenity, talk to a healthcare professional or refer to the Instructions for Use.

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For more information about Plenity, Roman, Ro and more, visit our FAQ page. To speak to a care representative, give us a call at (888) 798-8686 or email us at [email protected].

What is Plenity made of?

Plenity contains a hydrogel made of naturally derived building blocks, which absorbs a significant amount of water once in the stomach. Plenity is made from naturally derived substances: carboxymethyl cellulose (modified cellulose – cellulose is the fiber found in vegetables and plants) and citric acid (found in many fruits like lemons and limes).

How does Plenity work?

When Plenity is combined with water, small Plenity hydrogel particles are formed. Plenity particles are about the size of a grain of salt or sugar. After ingestion, Plenity capsules release thousands of these hydrogel particles and each particle absorbs about 100 times its weight in water. These hydrated hydrogel particles do not clump together, rather they mix with food and promote a sense of fullness. 

When will I begin to lose weight?

Weight loss is a gradual process and every experience is different.  But on average the sensation of fullness occurs early and is followed a few weeks later by weight loss.  In clinical studies, people taking Plenity with diet and exercise had greater weight loss compared to people doing diet and exercise alone as early as 4 weeks.

Who and what is Plenity for?

Plenity has been cleared for use in adults, not in children or adolescents. Plenity aids in weight management for overweight and obese adults with a Body Mass Index (BMI) of 25-40 kg/m^2, when used in conjunction with diet and exercise. 

You can calculate your BMI by entering your height and weight into a calculator that can be found at:

What is the likelihood that Plenity will work for me?

In the pivotal GLOW study using Plenity, nearly 60% of participants achieved >= 5% body weight loss and 27% of participants achieved >= 10% body weight loss.

Do I need to be on a specific diet or exercise regimen when taking Plenity?

Having a balanced diet with 30 minutes of daily physical activity is part of a healthy lifestyle.  Plenity can work with any diet or nutrition plan and since Plenity makes you feel fuller, eating less can be easier.

Is Plenity a drug?

No.  Plenity is not a drug because it is not absorbed into your bloodstream, does not alter the function of your cells or your organs, and is not processed or metabolized by your liver or kidneys. Plenity is made of naturally derived building blocks that work locally in your GI tract, it is never absorbed into your body, and acts mechanically to make you feel full.

Does Plenity contain any common allergens?

Plenity does not contain or produce gluten, soy, wheat, peanuts, shellfish, lactose, dairy, sugar, alcohol, latex, or mercury. Nor does it contain any dyes, preservatives, or ingredients related to Para-Aminobenzoic Acid. Plenity is made from naturally derived substances: carboxymethyl cellulose (modified cellulose – cellulose is the fiber found in vegetables and plants) and citric acid (found in many fruits like lemons and limes).

What are the most common side effects of Plenity?

In the pivotal GLOW study, there was no overall difference between treatment and placebo group. The most common side effects of Plenity were diarrhea 13% (placebo 9%), abdominal distension 12% (placebo 7%), infrequent bowel movements 9% (placebo 5%), and flatulence 9% (placebo 5%). These gastrointestinal side effects were usually mild to moderate in intensity and resolved in a matter of days or weeks.