weight management


Manage your weight and still enjoy your meals. Plenity is the first and only FDA-cleared weight management tool made from naturally derived building blocks. Plenity helps you feel full, eat less, and lose weight.

  • In clinical trials, 59% of Plenity responders lost on average 10% of their body weight (22 pounds) in six months.
  • Indicated to aid in weight management in adults with excess weight or obesity, Body Mass Index (BMI) of 25 to 40 kg/㎡, when used in conjunction with diet and exercise.
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Treatment benefits

Stimulant free and non-habit forming

Clinically tested and FDA-cleared

Free 2-day shipping

Free and unlimited follow-ups with a healthcare professional

How it works

Plenity, made from naturally derived building blocks, is three capsules that help you feel full, eat less, and lose weight. You’ll take the capsules with 16 ounces (2 cups) of water before lunch and dinner. Plenity absorbs the water you drink and mixes with the food you eat. And as you continue to use it, you feel fuller throughout the day.

Take the capsules

Take three Plenity capsules before you eat lunch and dinner.

Drink water

Pair your Plenity capsules with a 16-ounce bottle of water or two 8-ounce glasses of water with each dose.

Feel fuller

Wait 20 minutes to eat after taking your Plenity capsules, and you’ll feel full after eating smaller portions.

*The percentage of responders, a co-primary endpoint, or the percentage of patients who lost ≥5% of body weight, achieved clinically meaningful weight loss with Plenity vs placebo (59% vs 42%; P=0.0008). The study did not meet the predefined weight loss super-superiority margin of 3% over placebo.

Learn more about Plenity’s clinical trial—Gelesis loss of weight (GLOW) study

In a 24-week clinical trial called GLOW (Gelesis Loss of Weight), Plenity or placebo was given to 436 adults who were overweight or had obesity, in conjunction with diet and exercise.

The study was designed to measure: efficacy of at least 35% of individuals receiving Plenity lost 5% of their body weight, and a Placebo-adjusted weight loss of 3%.

There was no difference between placebo and Plenity in the overall incidence of adverse events.

You’ve got questions? We’ve got answers.

Plenity is an innovative weight management tool. And since Plenity is new, we encourage you to explore a few important questions and find out if Plenity is right for you.

Is it safe?

Plenity has been shown in a clinical study to have a proven safety profile and is as well-tolerated as a placebo (a capsule with inactive ingredients).

Is it natural?

Plenity is made from two naturally derived building blocks—cellulose (the primary cell wall of green plants) and citric acid (naturally found in citrus fruits).

How long can I take it?

Plenity is not habit-forming or addictive and there is no restriction on how long it can be used.

Are there any side effects?

The most common side effects were fullness, bloating, flatulence, diarrhea, and/or abdominal pain. There was no difference between placebo and Plenity in the overall incidence of adverse events.

Your day-to-day life with Plenity

Watch this video to find out how Plenity would look in your daily routine.

Important Safety Information

Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity.

To avoid impact on the absorption of medications:

  • For all medications that should be taken with food, take them after starting a meal.
  • For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician.

Contact a healthcare professional right away if problems occur. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your provider.

Plenity is a prescription-only therapy. For the safe and proper use of Plenity, talk to a healthcare professional or refer to the Instructions for Use.