Allergy relief

Fluticasone Propionate Nasal Spray

Generic Flonase

Non-drowsy nasal steroid spray.

Decreases runny, itchy, congested nasal passages.

Can also relieve itchy and watery eyes.

Safe for use every day.


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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a healthcare provider.

How to Use

Spray the medication in each nostril as prescribed.

If you experience nosebleeds and/or headaches, contact your doctor through

Common Side Effects

Nosebleed from spraying the medication directly on the septum.

Transparent Manufacturing

Fluticasone propionate is manufactured in the USA.

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Allergy medication works best when taken every day.

Be sure to continue using your medication as directed, even after your symptoms have improved.

Members can message their healthcare professional any time with treatment questions or requests.

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What is fluticasone propionate?

Fluticasone propionate is a type of medication known as a second-generation glucocorticoid. Glucocorticoids are corticosteroid hormones that are effective at reducing inflammation. Corticosteroid hormones are not the same thing as anabolic steroids, which are the steroids commonly associated with athletic enhancement. By reducing inflammation, fluticasone propionate decreases nasal congestion.

How does fluticasone propionate differ from Flonase?

Fluticasone propionate is the generic form of the brand name medication, Flonase. The two medications are considered equivalent. The U.S. Food and Drug Administration requires that generic drugs demonstrate bioequivalence to the brand name drug, which means they act the same way in the body and are expected to produce the same effects as the original brand name drug.

How does fluticasone propionate work?

Researchers are not entirely sure how fluticasone propionate works but it is known to have a wide range of effects on different immune cells and chemicals that cause inflammation, including mast cells, histamine, and leukotrienes.

How should fluticasone propionate be taken?

Fluticasone propionate comes as a nasal spray that delivers the medication directly to the inside of the nose. To use it, pump two sprays in each nostril one time per day. If possible, try to take the medication at the same time each day. To properly use the nasal spray, follow the directions for use that accompany the medication. You may also find these steps helpful:

  1. Before first use, pump the bottle about 5 times until a mist appears. Also do this if the product hasn’t been used in 3+ days.
  2. Shake the bottle gently.
  3. Blow your nose to clear it before each use.
  4. Keep your head upright and insert the applicator tip into your nostril.
  5. Hold the applicator tip inside your nose and point the tip towards the outer corner of your eye. It’s helpful to use the opposite hand with each nostril to ensure that the tip is facing the outer corner of your eye. The goal is NOT to spray the medication straight back. You also do not want to point the tip towards the midline of the nose (where the septum is) because that can cause nosebleeds.
  6. Close off the other nostril with a finger. Breathe in, and press the pump to release the spray while inhaling.
  7. Hold your breath for a few seconds, and breathe out slowly through your mouth after each spray.
  8. Alternate nostrils after each pump (e.g. right-left-right-left)
  9. After using the spray, gently sniff.
  10. Wipe the tip of the applicator with a clean tissue after each use.

What if you miss a dose?

If you accidentally miss a dose, take it when you remember. However, if your next dose is supposed to be within a couple of hours, skip the missed dose and resume your normal schedule. Do not take a double dose.

What if you take more than you are prescribed?

Using too much fluticasone propionate at one time is generally not considered dangerous. However, chronic overuse may cause specific signs and symptoms. Using greater than what is recommended by your physician can lead to trauma and irritation of the lining of the inside of the nose, which can lead to nosebleeds. Also, fluticasone is a corticosteroid which can affect other parts of your body aside from your nose. Long-term use of high levels of corticosteroid hormones can cause symptoms such as thinning skin, changes in body fat distribution, and increased acne, bone loss, blood sugar problems, or facial hair. If you are experiencing worrisome symptoms, contact a healthcare provider.

Is buying fluticasone propionate online safe?

With Rory, you can always be sure you are getting genuine medication. Rory dispenses drugs that are FDA approved and manufactured by pharmaceutical companies that adhere to the FDA’s manufacturing standards for finished drug products. In fact, you will likely find many of the same manufacturers we use in your local pharmacy.

Side effects

Fluticasone propionate may cause nosebleeds. If this is occurring, please stop using the medication and see your in-person healthcare provider.

Additional possible side effects include ocular hypertension, nasal septum perforation, increased intracranial pressure, keratitis, visual impairment, skin atrophy, anaphylactoid reactions, angioedema, Churg-Strauss syndrome, vasculitis, muscle paralysis, bronchospasm, cholecystitis, dysphonia, conjunctivitis, contact dermatitis, migraine, cataracts, withdrawal, hypothalamic-pituitary-adrenal (HPA) suppression, adrenocortical insufficiency, Cushing’s syndrome, growth inhibition, elevated hepatic enzymes, blurred vision, hematoma, erythema, skin ulcer, impaired wound healing, hypotension, eosinophilia, osteopenia, osteoporosis, depression, wheezing, dyspnea, palpitations, glycosuria, oral ulceration, hyperglycemia, leukopenia, thrombocytopenia, bleeding, tolerance, headache, sinusitis, fatigue, malaise, pharyngitis, nasal congestion, throat irritation, arthralgia, insomnia, rhinitis, musculoskeletal pain, hoarseness, cough, rash, xerosis, fever, epistaxis, pruritus, skin irritation, back pain, nasal irritation, ocular irritation, dizziness, laryngitis, rhinorrhea, sneezing, dysmenorrhea, otalgia, dental pain, menstrual irregularity, folliculitis, xerophthalmia, urticaria, striae, acneiform rash, telangiectasia, skin hypopigmentation, vesicular rash, miliaria, purpura, acne vulgaris, hypertrichosis, ecchymosis, flushing, restlessness, irritability, agitation, anxiety, muscle cramps, rhinalgia, anosmia, nasal dryness, and weight gain.

Important safety information

The information here is taken from the Prescriber’s Digital Reference (PDR), which can be found here.

Contraindications & precautions

  • Fluticasone propionate should not be used by anybody who has an allergy or sensitivity to fluticasone propionate or other corticosteroids.
  • Fluticasone propionate should not be used by anybody who is pregnant or nursing.
  • Fluticasone propionate is contraindicated in patients with corticosteroid hypersensitivity, milk protein hypersensitivity, acute bronchospasm, or status asthmaticus.
  • Fluticasone propionate should be used with caution in geriatric patients, tobacco smokers, and patients with Cushing’s syndrome, hypothalamic-pituitary-adrenal (HPA) suppression, occlusive dressing, skin abrasion, surgery, diabetes mellitus, recent nasal septal perforation, recent nasal surgery, recent nasal trauma, fungal infection, herpes infection, measles, tuberculosis, varicella, viral infection, malnutrition, osteoporosis, hepatic disease, acne rosacea, acne vulgaris, perioral dermatitis, peripheral vascular disease, skin atrophy, cataracts, glaucoma, increased intraocular pressure, ocular exposure, or formaldehyde hypersensitivity.

Drug interactions

  • Fluticasone propionate should not be used with drugs that inhibit CYP3A4, including ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin, conivaptan, lopinavir, nefazodone, and voriconazole.
  • The full list of medication interactions is listed in the PDR.

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