Allergy relief


Generic Singulair

Montelukast sodium

Non-drowsy oral allergy medication.

FDA-approved to relieve symptoms of allergic rhinitis.

Montelukast attacks allergies via a different pathway.

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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a healthcare provider.

How to Use

Take 1 tablet by mouth every night at bedtime. May be taken with or without food.

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Monteleukast is manufactured in the USA.

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Allergy medication works best when taken every day.

Be sure to continue using your medication as directed, even after your symptoms have improved.

Members can message their healthcare professional any time with treatment questions or requests.

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What is montelukast?

Montelukast is a type of medication known as a leukotriene receptor antagonist. Leukotriene receptor antagonists block the action of leukotrienes, inflammatory chemicals the body releases during an allergic reaction. The release of leukotrienes leads to a number of symptoms including nasal congestion. Montelukast helps stop these symptoms from happening.

How does montelukast differ from Singulair?

Montelukast is the generic form of the brand name medication, Singulair. The two medications are considered equivalent. The U.S. Food and Drug Administration requires that generic drugs demonstrate bioequivalence to the brand name drug, which means they act the same way in the body and are expected to produce the same effects as the original brand name drug.

How does montelukast work?

Montelukast works by blocking cysteinyl leukotriene receptors, which can be activated by the chemical leukotriene D4. When the body is exposed to an allergen, immune cells (including mast cells and basophils) release leukotriene D4. Since montelukast blocks leukotriene D4 from activating the cysteinyl leukotriene receptors, the symptoms that are typically caused by leukotriene D4 are lessened.

How should montelukast be taken?

Montelukast is an oral medication that should be taken by mouth once daily in the evening. If possible, try to take the medication at the same time each day.

What if you miss a dose?

If you accidentally miss a dose, skip the missed dose and resume your normal schedule the following day when your next dose is due. Do not take more than one dose in 24 hours.

What if you take more than you are prescribed?

Taking extra doses of montelukast in a 24-hour period may result in abdominal pain, vomiting, difficulty sleeping, headache, thirst, and restlessness. There is no specific treatment for a montelukast overdose. If you are experiencing symptoms, contact poison control and a healthcare provider immediately.

While overdose is possible, death is unlikely to occur from taking an extra daily dose by accident. In tests done on mice, the maximum non-lethal dose of montelukast was approximately 335 times the daily dose in humans. In tests done on rats, the maximum non-lethal dose of montelukast was approximately 230 times the daily dose in humans.

Is buying montelukast online safe?

With Rory, you can always be sure you are getting genuine medication. Rory dispenses drugs that are FDA approved and manufactured by pharmaceutical companies that adhere to the FDA’s manufacturing standards for finished drug products. In fact, you will likely find many of the same manufacturers we use in your local pharmacy.

Side effects

Montelukast is generally well tolerated but may cause headaches.

Additional possible side effects include Churg-Strauss syndrome, vasculitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, pancreatitis, erythema nodosum, anaphylactoid reactions, angioedema, seizures, suicidal ideation, pyuria, atopic dermatitis, myopia, wheezing, gastritis, conjunctivitis, elevated hepatic enzymes, eosinophilia, hepatitis, edema, thrombocytopenia, palpitations, bleeding, depression, confusion, memory impairment, impulse control symptoms, hostility, dysphemia, hallucinations, urinary incontinence, dizziness, fatigue, asthenia, nasal congestion, nausea, dyspepsia, rash, vomiting, sinusitis, fever, laryngitis, pharyngitis, abdominal pain, headache, cough, urticaria, infection, diarrhea, rhinitis, rhinorrhea, epistaxis, influenza, myalgia, weight loss, pruritus, arthralgia, hypoesthesia, muscle cramps, drowsiness, paresthesias, ecchymosis, somnambulism, nightmares, abnormal dreams, tremor, anxiety, agitation, irritability, restlessness, and insomnia.

Important safety information

The information here is taken from the Prescriber’s Digital Reference (PDR), which can be found here.

Contraindications & precautions

  • Montelukast should not be used by anybody who has an allergy or sensitivity to montelukast.
  • Montelukast should not be used by anybody who is pregnant or nursing.
  • Montelukast is not an effective treatment for patients with acute bronchospasm or status asthmaticus.
  • Montelukast should be used with caution in geriatric patients and patients with phenylketonuria, behavioral changes, depression, psychiatric event, suicidal ideation, alcoholism, hepatic disease, hepatitis, jaundice, or corticosteroid withdrawal.

Drug interactions

  • Montelukast has minor interactions with the medications atropine, hyoscyamine, phenobarbital, scopolamine, belladonna alkaloids, ergotamine, carbamazepine, enzalutamide, gemfibrozil, hydantoins, lumacaftor, ivacaftor, mitotane, primidone, rifamycins, St. John’s Wort, and warfarin.
  • The full list of medication interactions is listed in the PDR.

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