Sex

Vaginal Estradiol Cream 0.01%

Quarterly plan: $60.00 / month

A prescription cream containing plant-derived estrogen to treat vaginal dryness.

• Helps to relieve the symptoms associated with moderate to severe vaginal dryness such as itching, burning, and irritation
• Estrogen is the oldest and most effective prescription medication for the treatment of vaginal dryness
• North American Menopause Society has stated that topical estrogen therapy is an effective treatment and safer than oral estrogen
• Use the prescribed amount before going to bed

This information isn’t a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns, please talk to your doctor.

Vaginal Estradiol is not suitable for patients with known, suspected or history of breast cancer or other estrogen-sensitive cancers or with blood clotting disorders or abnormal vaginal bleeding. Vaginal estradiol has an FDA boxed warning related to these conditions. Women who might be or are pregnant or breastfeeding should not use vaginal estradiol. To learn more about risks and benefits, including the boxed warning, click for important safety information.

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Vaginal Estradiol Cream 0.01%

The science behind vaginal estradiol.

Vaginal estradiol is a lower dose, local estrogen cream that’s applied directly to the vagina. Several studies have shown that vaginal estradiol is an effective treatment for vaginal dryness. Estradiol may help to restore your vaginal tissue, which helps to increase production of your natural vaginal lubrication and also strengthen and thicken the vaginal tissue.

This rejuvenation of the vaginal tissue helps to improve vaginal dryness, burning, itching, as well as discomfort during sex. There can also be added benefits of vaginal estradiol such as improvements in urinary incontinence.

If a prescription is appropriate, you’ll receive a customized dose and treatment plan from your Rory-affiliated physician.

Frequently Asked Questions

What is vaginal estradiol?

Vaginal Estradiol 0.01% is a prescription cream containing plant-derived estrogen that is FDA-approved to treat the symptoms of vulvar and vaginal atrophy associated with  menopause, including moderate to severe vaginal dryness (e.g., itching and burning)

Vaginal estradiol cream is not appropriate for everyone. To learn more about who should not use vaginal estradiol cream and the side effects that it may cause, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see the FAQ below regarding side effects and the important safety information for vaginal estradiol cream.

How do I use vaginal estradiol?

Vaginal estradiol is a cream that comes with a calibrated applicator that has markings for 1, 2, 3 or 4 grams. Use the applicator to apply the prescribed amount of cream into the vagina.

To minimize leakage of the cream, apply the medication at night before going to bed. Always follow your physician’s instructions. If you have any questions about your medication, please contact your Rory-affiliated provider on your My Ro account.

What are the potential side effects associated with using vaginal estradiol?


Most patients tolerate vaginal estradiol well, but, as with any medication, vaginal estradiol can have side effects. Below are a few potential side effects:

• Headache
• Back pain
• Weight gain
• Skin irritation, itching
• Diarrhea
• Nausea
• Abdominal pain
• Period cramps, vaginal bleeding
• Pain in the breasts

Vaginal estradiol cream is not appropriate for everyone. Like most medications, vaginal estradiol can cause serious drug interactions and side effects that you should understand before using it for vaginal dryness. If you choose to complete an online visit through Rory, your Rory-affiliated physician will be available to discuss side effects with you. To learn more about risks and benefits, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see important safety information.

Will my vaginal symptoms go away on their own, like hot flashes do?

Because it is caused by the decline of estrogen in the body, vaginal dryness tends to be a chronic condition. While other menopausal symptoms, like hot flashes or night sweats, end over time, symptoms of vaginal dryness do not.

Can personal lubricants or moisturizers help with vaginal dryness?

Personal lubricants and moisturizers can be helpful to provide relief from the symptoms of vaginal dryness like burning, itching or painful intercourse—and they can be a great complement to vaginal estrogen therapy to provide additional relief during sex. However, personal lubricants and moisturizers do not treat the underlying cause of the symptoms, and their results are temporary.

Is estrogen therapy safe?

Vaginal estradiol is a local estrogen cream that’s applied directly to the vagina. The amount of estrogen contained in vaginal estradiol cream is lower than the dose of estrogen used in oral hormone replacement therapies (HRT). However, it is essential to consider the safety and side effects of oral estrogen when considering treatment with vaginal estradiol cream.

Vaginal Estradiol is not suitable for patients with known, suspected or a history of breast cancer or other estrogen-sensitive cancers or with blood clotting disorders or abnormal vaginal bleeding. Vaginal estradiol has an FDA boxed warning related to these conditions. Women who might be or are pregnant or breastfeeding should not use vaginal estradiol. To learn more about risks and benefits, including the boxed warning, click for important safety information.